Spliceosome
| PAG Title | Spliceosome |
| PAG ID | WIG000620 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 10,406 |
| Information Content | Rich |
| Other IDs | M2044 |
| Base PAG ID | WIG000620 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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